Is GERD a Factor in Osteonecrosis of the Jaw? Evidence of Pathology Linked to G6PD Deficiency and Sulfomucins

Table 2

Evidence that ONJ is associated with vitamin C deficiency. The symptoms associated with scurvy as defined in [33] are all significantly overrepresented (>95% CI) in association with ONJ compared to NOT ONJ, many by a wide margin.

Side effect	Count 1	Count 2	f1/f2	Score
Bleeding gums	841	1792	33.5	971
Impaired wound healing	304	716	30.3	968
Hyperkeratosis	274	925	21.2	955
Joint effusions	401	1742	16.5	943
Inflamed gums	458	2231	14.6	936
Sjögren’s	85	531	11.5	920
Ecchymosis	226	1437	11.2	918
Infection	15953	122729	9.3	903
Folliculitis	73	582	9.0	900
Dry eye	331	2796	8.5	895
Dry mouth	608	7289	6.0	857
Petechiae	63	1125	4.0	801
Muscular weakness	734	13614	3.9	795
Anaemia	4602	86759	3.8	792
Haemorrhage	2996	62389	3.4	775
Fatigue	2653	62014	3.1	754
Myalgia	1215	30573	2.9	741
Arthralgia	3012	78226	2.8	734
Depression	3292	106774	2.2	689
Total count	10580	762002	1.0	500