Table 2: Evidence that ONJ is associated with vitamin C deficiency. The symptoms associated with scurvy as defined in [33] are all significantly overrepresented (>95% CI) in association with ONJ compared to NOT ONJ, many by a wide margin.

Side effectCount 1Count 2f1/f2Score

Bleeding gums841179233.5971
Impaired wound healing30471630.3968
Hyperkeratosis27492521.2955
Joint effusions401174216.5943
Inflamed gums458223114.6936
Sjögren’s8553111.5920
Ecchymosis226143711.2918
Infection159531227299.3903
Folliculitis735829.0900
Dry eye33127968.5895
Dry mouth60872896.0857
Petechiae6311254.0801
Muscular weakness734136143.9795
Anaemia4602867593.8792
Haemorrhage2996623893.4775
Fatigue2653620143.1754
Myalgia1215305732.9741
Arthralgia3012782262.8734
Depression32921067742.2689
Total count105807620021.0500