Table 6: Evidence that ONJ is linked to adrenal insufficiency. Not only is adrenal insufficiency itself highly overrepresented in association with ONJ compared to NOT ONJ, but also the various symptoms associated with adrenal insufficiency are also unusually common among sufferers of ONJ. The score is defined in (1).

Side effectCount 1Count 2f1/f2Score

Any adrenal591154127.6965
Addison’s disease3510124.6961
Adrenal insufficiency13356116.9944
Orthostatic hypotension21615929.8907
Myopathy62851688.7897
Vertigo64765267.1877
Hypoglycaemia22529305.5846
Muscular weakness734136143.9795
Diarrhea2265489013.3769
Fatigue2653620143.1754
Vomiting1594489342.3701
Nausea2186747962.1677
Disorientation10746061.7625