Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2016 (2016), Article ID 8486406, 9 pages
http://dx.doi.org/10.1155/2016/8486406
Review Article

Association between Vascular Endothelial Growth Factor Polymorphisms and Age-Related Macular Degeneration: An Updated Meta-Analysis

Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Catania, Via S. Sofia 87, 95123 Catania, Italy

Received 3 August 2016; Accepted 2 November 2016

Academic Editor: Taina K. Lajunen

Copyright © 2016 Martina Barchitta and Andrea Maugeri. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Pascolini, S. P. Mariotti, G. P. Pokharel et al., “2002 Global update of available data on visual impairment: a compilation of population-based prevalence studies,” Ophthalmic Epidemiology, vol. 11, no. 2, pp. 67–115, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. R. D. Jager, W. F. Mieler, and J. W. Miller, “Age-related macular degeneration,” The New England Journal of Medicine, vol. 358, no. 24, pp. 2544–2617, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. X. Ding, M. Patel, and C.-C. Chan, “Molecular pathology of age-related macular degeneration,” Progress in Retinal and Eye Research, vol. 28, no. 1, pp. 1–18, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. F. L. Ferris, M. D. Davis, T. E. Clemons et al., “A simplified severity scale for age-related macular degeneration: AREDS Report No. 18,” Archives of Ophthalmology, vol. 123, no. 11, pp. 1570–1574, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Tong, J. Liao, Y. Zhang, J. Zhou, H. Zhang, and M. Mao, “LOC387715/HTRA1 gene polymorphisms and susceptibility to agerelated macular degeneration: a HuGE review and meta-analysis,” Molecular Vision, vol. 16, pp. 1958–1981, 2010. View at Google Scholar · View at Scopus
  6. H. Esfandiary, U. Chakravarthy, C. Patterson, I. Young, and A. E. Hughes, “Association study of detoxification genes in age related macular degeneration,” British Journal of Ophthalmology, vol. 89, no. 4, pp. 470–474, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Swaroop, K. E. H. Branham, W. Chen, and G. Abecasis, “Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits,” Human Molecular Genetics, vol. 16, no. 2, pp. R174–R182, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. J. R. W. Yates and A. T. Moore, “Genetic susceptibility to age related macular degeneration,” Journal of Medical Genetics, vol. 37, no. 2, pp. 83–87, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. S. C. Sacca, C. Bolognesi, A. Battistella, A. Bagnis, and A. Izzotti, “Gene-environment interactions in ocular diseases,” Mutation Research—Fundamental and Molecular Mechanisms of Mutagenesis, vol. 667, no. 1-2, pp. 98–117, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Y. Ting, T. K. Lee, and I. M. MacDonald, “Genetics of age-related macular degeneration,” Current Opinion in Ophthalmology, vol. 20, pp. 369–376, 2009. View at Google Scholar
  11. L. M. Hjelmeland, “Dark matters in AMD genetics: epigenetics and stochasticity,” Investigative Ophthalmology and Visual Science, vol. 52, no. 3, pp. 1622–1631, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Ferrara, “Molecular and biological properties of vascular endothelial growth factor,” Journal of Molecular Medicine, vol. 77, no. 7, pp. 527–543, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. J. S. Penn, A. Madan, R. B. Caldwell, M. Bartoli, R. W. Caldwell, and M. E. Hartnett, “Vascular endothelial growth factor in eye disease,” Progress in Retinal and Eye Research, vol. 27, no. 4, pp. 331–371, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. P. K. Kaiser, “Antivascular endothelial growth factor agents and their development: therapeutic implications in ocular diseases,” American Journal of Ophthalmology, vol. 142, no. 4, pp. 660–668, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. V. Vincenti, C. Cassano, M. Rocchi, and M. G. Persico, “Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3,” Circulation, vol. 93, no. 8, pp. 1493–1495, 1996. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Ferrara, H.-P. Gerber, and J. LeCouter, “The biology of VEGF and its receptors,” Nature Medicine, vol. 9, no. 6, pp. 669–676, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. F. M. Gonçalves, A. Martins-Oliveira, J. G. Speciali et al., “Vascular endothelial growth factor genetic polymorphisms and haplotypes in women with migraine,” DNA and Cell Biology, vol. 29, no. 7, pp. 357–362, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Janik-Papis, M. Zaras, A. Krzyzanowska et al., “Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a Polish population,” Experimental and Molecular Pathology, vol. 87, no. 3, pp. 234–238, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. A. J. Churchill, J. G. Carter, H. C. Lovell et al., “VEGF polymorphisms are associated with neovascular age-related macular degeneration,” Human Molecular Genetics, vol. 15, no. 19, pp. 2955–2961, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. J.-M. Lin, L. Wan, Y.-Y. Tsai et al., “Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration,” American Journal of Ophthalmology, vol. 145, no. 6, pp. 1045–1051, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Lu, Y. Shi, C. Xue, J. Yin, and Z. Huang, “Pooled-analysis of the associations between three polymorphisms in the VEGF gene and age-related macular degeneration,” Molecular Biology Reports, vol. 39, no. 6, pp. 6547–6553, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Huang, Y. Xu, X. Li, and W. Wang, “Vascular endothelial growth factor A polymorphisms and age-related macular degeneration: a systematic review and meta-analysis,” Molecular Vision, vol. 19, pp. 1211–1221, 2013. View at Google Scholar · View at Scopus
  23. Y. Liu, S. Hou, W. Lang et al., “Roles of three common VEGF polymorphisms in the risk of age-related macular degeneration,” Genetic Testing and Molecular Biomarkers, vol. 18, no. 4, pp. 245–252, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Moher, A. Liberati, J. Tetzlaff, D. G. Altman, and PRISMA Group, “Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement,” International Journal of Surgery, vol. 8, no. 5, pp. 336–341, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. A. J. Richardson, F. M. A. Islam, R. H. Guymer, M. Cain, and P. N. Baird, “A tag-single nucleotide polymorphisms approach to the vascular endothelial growth factor-A gene in age-related macular degeneration,” Molecular Vision, vol. 13, pp. 2148–2152, 2007. View at Google Scholar · View at Scopus
  26. J. P. Szaflik, J. Błasiak, A. Krzyanowska et al., “Distribution of the C-460T polymorphism of the vascular endothelial growth factor gene in age-related macular degeneration,” Klinika Oczna, vol. 111, no. 4–6, pp. 125–127, 2009. View at Google Scholar · View at Scopus
  27. Y. Qu, H. Dai, F. Zhou et al., “Vascular endothelial growth factor gene polymorphisms and risk of neovascular age-related macular degeneration in a Chinese cohort,” Ophthalmic Research, vol. 45, no. 3, pp. 142–148, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. F. Cruz-González, C. Cieza-Borrella, L. Cabrillo-Estévez, C. Cañete-Campos, F. Escudero-Domínguez, and R. González-Sarmiento, “VEGF A (rs699947 and rs833061) and VEGFR2 (rs2071559) gene polymorphisms are not associated with AMD susceptibility in a Spanish population,” Current Eye Research, vol. 38, no. 12, pp. 1274–1277, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. L. N. Almeida, R. Melilo-Carolino, C. E. Veloso et al., “Homozygosity for the +674C>T polymorphism on VEGF gene is associated with age-related macular degeneration in a Brazilian cohort,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 250, no. 2, pp. 185–189, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Galan, A. Ferlin, L. Caretti et al., “Association of age-related macular degeneration with polymorphisms in vascular endothelial growth factor and its receptor,” Ophthalmology, vol. 117, no. 9, pp. 1769–1774, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Jiang, G. Liang, L. Wang, J. Jiang, G. Du, and Y. Huang, “Association between vascular endothelial growth factor +936 C/T gene polymorphism and age-related macular degeneration,” Journal of International Medical Research, vol. 41, no. 2, pp. 317–324, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. F. T. I. Gonçalves, S. M. Cezario, M. C. J. Calastri et al., “Influence of VEGF-C936T genetic variant on age-related macular degeneration,” Arquivos Brasileiros de Oftalmologia, vol. 78, no. 5, pp. 290–294, 2015. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Tian, W. Yu, X. Qin et al., “Association of genetic polymorphisms and age-related macular degeneration in Chinese population,” Investigative Ophthalmology and Visual Science, vol. 53, no. 7, pp. 4262–4269, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Thakkinstian, P. McElduff, C. D'Este, D. Duffy, and J. Attia, “A method for meta-analysis of molecular association studies,” Statistics in Medicine, vol. 24, no. 9, pp. 1291–1306, 2005. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus
  35. J. P. T. Higgins and S. G. Thompson, “Quantifying heterogeneity in a meta-analysis,” Statistics in Medicine, vol. 21, no. 11, pp. 1539–1558, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. J. P. T. Higgins and S. Green, Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0, The Cochrane Collaboration, 2008.
  37. I. Immonen, S. Seitsonen, P. Tommila et al., “Vascular endothelial growth factor gene variation and the response to photodynamic therapy in age-related macular degeneration,” Ophthalmology, vol. 117, no. 1, pp. 103–108, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. Y. Bulgu, G. O. Cetin, V. Caner, E. N. Cetin, V. Yaylali, and C. Yildirim, “Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population,” International Journal of Ophthalmology, vol. 7, no. 5, pp. 773–777, 2014. View at Publisher · View at Google Scholar
  39. S. S. Boekhoorn, A. Isaacs, A. G. Uitterlinden et al., “Polymorphisms in the vascular endothelial growth factor gene and risk of age-related macular degeneration: the rotterdam study,” Ophthalmology, vol. 115, no. 11, pp. 1899–1903, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. G. J. McKay, G. Silvestri, N. Orr, U. Chakravarthy, and A. E. Hughes, “VEGF and age-related macular degeneration,” Ophthalmology, vol. 116, no. 6, p. 1227, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. A. M. Fang, A. Y. Lee, M. Kulkarni, M. P. Osborn, and M. A. Brantley Jr., “Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration,” Molecular vision, vol. 15, pp. 2710–2719, 2009. View at Google Scholar · View at Scopus
  42. A. V. Chappelow and P. K. Kaiser, “Neovascular age-related macular degeneration: potential therapies,” Drugs, vol. 68, no. 8, pp. 1029–1036, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. M. La Cour, J. F. Kiilgaard, and M. H. Nissen, “Age-related macular degeneration: epidemiology and optimal treatment,” Drugs and Aging, vol. 19, no. 2, pp. 101–133, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. A. Stevens, J. Soden, P. E. Brenchley, S. Ralph, and D. W. Ray, “Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter,” Cancer Research, vol. 63, no. 4, pp. 812–816, 2003. View at Google Scholar · View at Scopus