Polymorphisms of the DNA Methyltransferase 1 Gene Predict Survival of Gastric Cancer Patients Receiving Tumorectomy

Table 2

Associations between the SNPs and clinical parameters of gastric cancer patients.

	rs10420321			rs16999593			rs2228612			rs2228611			rs2288349
	AA	AG + GG		TT	TC + CC		TT	TC + CC		GG	GA + AA		GG	GA + AA
	130	257		268	154		137	285		221	199		237	182
Gender
Male	31.9	68.1	0.334	62.4	37.6	0.532	31.4	68.6	0.650	53.3	46.7	0.885	55.2	44.8	0.538
Female	36.9	63.1		65.6	34.4		33.6	66.4		54.0	46.0		58.4	41.6
Age
≤60	34.5	65.5	0.600	64.7	35.3	0.571	34.0	66.0	0.392	54.0	46.0	0.837	52.6	47.4	0.154
>60	32.0	68.0		62.1	37.9		30.2	69.8		53.0	47.0		59.3	40.7
Tumor size
≤5 cm	33.6	66.4	0.982	64.8	35.2	0.668	33.1	66.9	0.807	50.6	49.4	0.400	57.0	43.0	0.933
>5 cm	33.5	66.5		62.8	37.2		31.9	68.1		54.7	45.3		56.6	43.4
Pathological type
Tubular adenocarcinoma	32.2	67.8	0.393	62.8	37.2	0.889	31.3	68.7	0.414	54.6	45.4	0.507	55.6	44.4	0.853
Signet ring cell carcinoma	36.8	63.2		65.2	34.8		30.4	69.6		47.8	52.2		56.5	43.5
Others	43.8	56.3		66.7	33.3		42.4	57.6		45.5	54.5		60.6	39.4
Differentiation
Well to moderate	37.6	62.4	0.191	61.1	38.9	0.501	34.4	65.6	0.458	57.7	42.3	0.152	54.5	45.5	0.646
Poor	31.1	68.9		64.4	35.6		30.9	69.1		50.5	49.5		56.8	43.2
TNM stage
I/II	29.6	70.4	0.065	62.9	37.1	0.710	29.4	70.6	0.183	52.0	48.0	0.618	58.5	41.5	0.354
III/IV	38.4	61.6		64.6	35.4		35.4	64.6		54.4	45.6		54.1	45.9
Lymph-vascular invasion
Absent	33.0	67.0	0.849	60.7	39.3	0.499	31.6	68.4	0.800	49.6	50.4	0.446	57.8	42.2	0.829
Present	34.0	66.0		64.2	35.8		32.9	67.1		53.7	46.3		56.6	43.4
Neural invasion
Absent	32.8	67.2	0.699	62.6	37.4	0.794	33.0	67.0	0.848	50.0	50.0	0.305	60.0	40.0	0.215
Present	34.7	65.3		63.8	36.2		32.1	67.9		55.0	45.0		54.1	45.9
Radical surgery
Yes	33.2	66.8	0.995	63.7	36.3	0.415	31.9	68.1	0.910	53.5	46.5	0.991	56.2	43.8	0.827
No	33.3	66.7		53.3	46.7		33.3	66.7		53.3	46.7		53.3	46.7
Chemotherapy
No	30.2	69.8	0.056	59.9	40.1	0.028	28.7	71.3	0.026	56.4	43.6	0.069	55.1	44.9	0.530
Yes	39.8	60.2		70.7	29.3		39.3	60.7		47.1	52.9		58.3	41.7