Polymorphisms of the DNA Methyltransferase 1 Gene Predict Survival of Gastric Cancer Patients Receiving Tumorectomy

Table 4

Multivariate Cox regression analysis on the survival of GC.

Variables	HR	95% CI	P
rs2228611 (GA/AA versus GG)	0.67	0.49–0.91	0.010
Sex (male versus female)	1.80	1.22–2.67	0.003
TNM stages (III + IV versus I + II)	4.76	3.28–6.90	<0.001
Tumor sizes (≥5 cm versus <5 cm)	1.56	1.13–2.16	0.007
Lymph-vascular invasion (present versus absent)	1.52	1.08–2.14	0.015
Surgical method (palliative versus radical surgery)	2.55	1.40–4.64	0.002
Chemotherapy (yes versus no)	0.69	0.50–0.96	0.029

HR: hazard ratio; CI: confidence interval.