Research Article

Analysis of Urinary Prostate-Specific Antigen Glycoforms in Samples of Prostate Cancer and Benign Prostate Hyperplasia

Table 5

Areas under the ROC curves of the target PSA glycopeptides.

Glycan compositionAUC valueCancer thresholdSensitivitySpecificity

H5N4S1F10.7381 ± 0.06610.009<0.47092.9%59.0%
Monosialylated0.7102 ± 0.06810.015<1.060100%47.5%
Sialylated 0.6938 ± 0.07630.025<1.26068.8%75%
Unfucosylated 0.6758 ± 0.06990.041<1.06587.5%60%
Total0.7242 ± 0.06620.009<1.81587.5%60%

AUC was calculated based on the samples which could be detected for the indicated glycoform or grouped glycoforms.