Research Article
Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification
Table 4
Unadjusted and multivariate adjusted associations of HOMA-IR and Adipo-IR indices with CAC > 0 and AVC > 0.
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Model 1: Adjusted for age, gender, and BMI. Model 2: Adjusted for age, gender, BMI, current smoking, physical activity index, statin use, SBP, DBP, LDL-C, HDL-C, triglycerides, and eGFR. Model 3: Adjusted for age, gender, BMI, current smoking, physical activity index, statin use, SBP, DBP, LDL-C, HDL-C, triglycerides, eGFR, hs C-reactive protein, adiponectin, type 2 diabetes, and visceral adipose tissue. Odds ratios (95% CI) for CAC > 0 or AVC > 0 in participants stratified by HOMA-IR or Adipo-IR quartiles (Q). Bold numbers: . HOMA-IR: homeostasis model assessment of insulin resistance; Adipo-IR: adipose tissue insulin resistance; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; LDL-C: low density lipoprotein cholesterol; HDL-C: high density lipoprotein cholesterol; eGFR: estimated glomerular filtration rate. |