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Disease Markers
Volume 2016 (2016), Article ID 9109743, 7 pages
http://dx.doi.org/10.1155/2016/9109743
Research Article

Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population

1Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China
2Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China
3Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China
4Department of Cardiovascular Disease, The First People’s Hospital of Foshan, Foshan 528000, China
5Institute of Laboratory Medicine, Guangdong Medical University, Dongguan 523808, China

Received 9 April 2016; Accepted 19 April 2016

Academic Editor: Manfredi Rizzo

Copyright © 2016 Sai-sai Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

lincRNA-p21 plays an important role in the pathogenesis and progression of coronary artery disease (CAD). To date, the biological significance of polymorphisms in lincRNA-p21 on CAD risk remains unknown. Here we aimed to evaluate the influence of lincRNA-p21 polymorphisms on individual susceptibility to CAD. Genotyping of four tagSNPs (rs9380586, rs4713998, rs6930083, and rs6931097) within lincRNA-p21 gene was performed in 615 CAD and 655 controls. The haplotype analysis showed that the haplotype G-A-A-G (rs9380586-rs4713998-rs6930083-rs6931097) was statistically significantly associated with the reduced risk for CAD (OR = 0.78, P = 0.023). Stratified analysis revealed that G-A-A-G haplotype was at a significantly lower risk for myocardial infarction (MI) (OR = 0.68, P = 0.010). We also found that haplotype G-A-A-G had a more pronounced decreased risk for premature CAD or MI subjects (OR = 0.67, P = 0.017 for premature CAD, and OR = 0.65, P = 0.041 for premature MI, resp.). Our data provide the first evidence that the G-A-A-G haplotype of lincRNA-p21 is associated with decreased risk of CAD and MI, particularly among premature CAD/MI in the Chinese Han population. Further studies with more subjects and in diverse ethnic populations are warranted to clarify the general validity of our findings.