Research Article
Influence of βS-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease
Table 1
Genotypes, SNP combinations, and restriction enzyme to determine each haplotype.
| Enzyme | Region | DNA fragment size (bp) | DNA fragment after cleavage | Haplotype | Bantu | Benin | Senegal | Cameroon | Arab-Indian |
|
Xmn I |
5′γ | 650 | | | | | | |
Hind III | γ | 780 | | | | | | | Hind III | γ | 760 | | | | | | |
Hinc II | β | 701 | | | | | | | Hinc II | 3′β | 590 | | | | | | |
Hinf I | 3′β | 380 | | | | | | |
|
|