Research Article

Influence of βS-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease

Table 1

Genotypes, SNP combinations, and restriction enzyme to determine each haplotype.

EnzymeRegionDNA fragment size (bp)DNA fragment after cleavageHaplotype
BantuBeninSenegalCameroonArab-Indian

Xmn I 5′γ650
Hind IIIγ780
Hind IIIγ760
Hinc IIβ701
Hinc II3′β590
Hinf I3′β380