Tyrosine Kinase Receptor Landscape in Lung Cancer: Therapeutical Implications

Figure 2

TKR alterations in lung cancer studies. Graphs showing the frequency of alterations in TKRs of relevance in the different lung cancer histologies found in different studies publicly available at http://www.cbioportal.org/. The different studies are designated by capital letters: (A) Imielinski et al., 2012 [5]; (B) MSKCC (Memorial Sloan Kettering Cancer Center) 2015; (C) TCGA, 2014 [6]; (D) Ding et al., 2008 [7]; (E) TCGA, 2012 [8]; (F) Peifer et al., 2012 [9]; (G) Rudin et al., 2012 [10]; and (H) George et al., Nature 2015 [11]. Only studies A, C, and E have information about copy number alterations. ADC: lung adenocarcinoma; SCC: lung squamous cell carcinoma; SCLC: small-cell lung cancer.