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Disease Markers
Volume 2016, Article ID 9391837, 7 pages
Review Article

The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis

1Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
2Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110001, China

Received 21 December 2015; Revised 1 March 2016; Accepted 16 March 2016

Academic Editor: Michele Malaguarnera

Copyright © 2016 Song Yue et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. In order to clarify previous ambiguous research conclusions, a meta-analysis was made to investigate the relationship between betatrophin levels in blood and type 2 diabetes mellitus (T2DM). Methods. We have searched all the English and Chinese references regarding the relationship between betatrophin and diabetes in database both manually and online. Strict criteria have been established to include and exclude articles, with Mean and Standard Deviation as statistics to evaluate strength of association. We have chosen either fixed- or random effect model according to heterogeneity inspection results and used Begg’s test and Egger’s test to analyze publication bias. Results. A total of 11 studies were included in this meta-analysis. Meta-analysis indicated a significant association between betatrophin and T2DM (Mean: 329.46; 95% confidence interval: 182.51 to 476.42, ). However, in the subgroup analysis, there was no significant statistic between betatrophin concentration and T2DM within Caucasian population (Mean: 98.40; 95% confidence interval: −1585.08 to 1781.88, ). Conclusions. Such relationship may suggest preference for association between betatrophin and T2DM in different population.