Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma

Figure 1

TNF signaling pathway anomalies through antiapoptotic signaling by TNFR1 helped by upregulation of TRAF1 and inhibition of proapoptotic TNFR1 signaling by BIRC1/3 caspase inactivation. Overexpression of CD40L could induce T-cell proliferation through CD40 receptor and TRAF1. IL2R overexpression leads to Jak2 and STAT4 activation which in turn induces oncogene c-MYC, LYN, and HCK expression. Meanwhile LYN and HCK take part in the feedback loop of antiapoptotic TNF signaling by producing endogenous TNF and thus stimulating TNFR1/2 antiapoptotic pathways.