Circulating Carbonic Anhydrase IX and Antiangiogenic Therapy in Breast Cancer

Table 1

CAIX levels in healthy control subjects ().

Timing plasma collection	Anticoagulant^#	CAIX, pg/mL
		Mean	Median	Range
Baseline, within 1 hr after phlebotomy	ACD	20.5	17.4	8.8–41.2
Baseline, 24 hrs after phlebotomy	ACD	21.1	16.4	8.7–36.4
Baseline, 48 hrs after phlebotomy	ACD	20.3	16.7	8.6–36.8
6-month follow-up, within 1 hr after phlebotomy	ACD	22.48	26.9	9.5–28.0
Baseline, within 1 hr after phlebotomy	Heparin	25.1	21.2	11.9–45.9
Baseline, 24 hrs after phlebotomy	Heparin	24.9	21.2	11.1–46.1
Baseline, 48 hrs after phlebotomy	Heparin	26.2	22.7	10.8–50.2

Referring to the time blood remained at room temperature prior to plasma separation, aliquoting, and freezing. ^#CAIX levels were on average 4.6 pg/mL higher in blood anticoagulated with heparin compared to ACD (). ACD: acid citrate dextrose; hr: hour; hrs: hours.