Expressions of Matrix Metalloproteinases 2, 7, and 9 in Carcinogenesis of Pancreatic Ductal Adenocarcinoma

Figure 1

Immunohistochemical expressions of MMP-2, MMP-7, and MMP-9 in normal ducts, tumor cells, and peritumoral stroma of PDAC. The lack of MMP-2 (a), MMP-7 (b), and MMP-9 (c) expressions was found in normal ducts. Positive reaction of MMP-9 (d) was noted in the cytoplasm of pancreatic adenocarcinoma cells. MMP-2 (d) overexpression was observed in the peritumoral stroma in the majority of PDAC cases and color reaction of MMP-7 was observed in the cytoplasm of both cancer cells and the stroma (e). Positive reaction of MMP-9 was noted in the cytoplasm of pancreatic adenocarcinoma cells (f).

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