Expressions of Matrix Metalloproteinases 2, 7, and 9 in Carcinogenesis of Pancreatic Ductal Adenocarcinoma

Table 2

Correlations between MMP-2, MMP-7, and MMP-9 expressions in tumor cells and clinicopathological parameters.

Variables	Patients, (%)	MMP-2		MMP-7		MMP-9
		R	p value	R	p value		p value
Gender
Male	23 (79.3)	0.460	0.013	−0.047	0.814	−0.042	0.804
Female	6 (20.7)
Age
≤60	14 (48.3)	−0.012	0.949	0.339	0.071	−0.383	0.046
>60	15 (51.7)
Inflammation
Absent	2 (6.9)	0.690	<0.001	0.053	0.782	0.081	0.666
Weak	9 (31.0)
Moderate	10 (34.5)
Strong	8 (27.6)
Desmoplasia
Poor	12 (41.4)	0.016	0.931	0.215	0.262	0.135	0.491
Prominent	17 (58.6)
Foci of hemorrhage
Absent	14 (48.3)	0.088	0.648	0.161	0.403	−0.271	0.162
Single	10 (34.5)
Numerous	5 (17.2)
Necrosis
Absent	16 (55.2)	−0.007	0.968	0.402	0.031	0.084	0.668
Weak	7 (24.1)
Moderate	6 (20.7)
Strong	0 (0.0)
MVD
Low	15 (51.7)	0.072	0.738	−0.682	<0.001	0.368	0.084
High	14 (48.3)
Adenocarcinoma type
Nonmucinous	26 (89.7)	−0.193	0.314	−0.139	0.495	−0.081	0.681
Mucinous	3 (10.3)
Grade of malignancy
G2	25 (86.2)	−0.156	0.417	−0.036	0.850	−0.129	0.512
G3	4 (13.8)
Lymph node involvement
Absent	17 (58.6)	0.024	0.899	−0.261	0.172	0.033	0.866
Present	12 (41.4)
Distant metastases
Absent	20 (69.0)	0.014	0.940	−0.193	0.313	−0.081	0.681
Present	9 (31.0)