Expressions of Matrix Metalloproteinases 2, 7, and 9 in Carcinogenesis of Pancreatic Ductal Adenocarcinoma

Table 3

Correlations between MMP-2, MMP-7, and MMP-9 expressions in peritumoral stroma cells and clinicopathological parameters.

Variables	Patients, (%)	MMP-2		MMP-7		MMP-9
			p value		p value		p value
Gender
Male	23 (79.3)	−0.051	0.793	−0.603	0.060	−0.237	0.215
Female	6 (20.7)
Age
≤60	14 (48.3)	0.199	0.299	0.029	0.879	−0.261	0.170
>60	15 (51.7)
Inflammation
Absent	2 (6.9)	0.263	0.167	0.132	0.494	−0.042	0.826
Weak	9 (31.0)
Moderate	10 (34.5)
Strong	8 (27.6)
Desmoplasia
Poor	12 (41.4)	0.033	0.864	−0.129	0.505	0.189	0.325
Prominent	17 (58.6)
Foci of hemorrhage
Absent	14 (48.3)	−0.198	0.302	−0.010	0.958	−0.164	0.395
Single	10 (34.5)
Numerous	5 (17.2)
Necrosis
Absent	16 (55.2)	−0.196	0.306	−0.050	0.796	0.121	0.529
Weak	7 (24.1)
Moderate	6 (20.7)
Strong	0 (0.0)
MVD
Low	15 (51.7)	−0.220	0.300	−0.022	0.916	−0.046	0.829
High	14 (48.3)
Adenocarcinoma type
Nonmucinous	26 (89.7)	−0.440	0.005	0.106	0.584	−0.194	0.313
Mucinous	3 (10.3)
Grade of malignancy
G2	25 (86.2)	−0.130	0.500	0.125	0.518	−0.021	0.912
G3	4 (13.8)
Lymph node involvement
Absent	17 (58.6)	−0.021	0.910	−0.176	0.360	−0.105	0.586
Present	12 (41.4)
Distant metastases
Absent	20 (69.0)	0.101	0.602	−0.106	0.582	−0.224	0.241
Present	9 (31.0)