Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22

Figure 1

Replication of EMSAs with (a) rs60687299, (b) rs977419, (c) rs977093, (d) rs9982601, and (e) rs28451064 probes using HepG2 and Huh-7 nuclear extract. Binding by both alleles was compared for all five SNPs. Only in (e) (rs28451064) is there strong binding for one allele but complete absence of binding for the other in both cell lines.