Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22

Table 2

Relationship between rs9982601 and expression of selected genes in seven tissues from GTEx (http://www.gtexportal.org/home/).

Gene	Tissue		Effect size (se)	value
MRPS6	Aortic artery	197	0.15 (0.05)	3.5 × 10^−3
MRPS6	Coronary artery	118	0.14 (0.11)	0.22
MRPS6	Tibial artery	285	0.15 (0.05)	1.8 × 10^−3
MRPS6	Atrial appendage	159	−0.02 (0.09)	0.88
MRPS6	Left ventricle (heart)	190	−0.16 (0.10)	0.09
MRPS6	Liver	97	−0.19 (0.14)	0.17
MRPS6	Whole blood	338	−0.09 (0.04)	0.04
KCNE2	Aortic artery	197	0.13 (0.07)	0.06
KCNE2	Coronary artery	118	0.09 (0.11)	0.43
KCNE2	Tibial artery	285	0.15 (0.06)	0.02
KCNE2	Atrial appendage	159	0.13 (0.16)	0.41
KCNE2	Left ventricle (heart)	190	−0.06 (0.14)	0.71
KCNE2	Liver	97	0.05 (0.15)	0.31
KCNE2	Whole blood	338	8.40 × 10^−3 (0.15)	0.92

Effect sizes refer to the effect of the minor allele on expression relative to the common allele. se = standard error.