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Disease Markers
Volume 2017 (2017), Article ID 1218254, 8 pages
https://doi.org/10.1155/2017/1218254
Research Article

Clinical Significance and Prognostic Value of the Expression of LAMP3 in Oral Squamous Cell Carcinoma

1Department of Stomatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
2Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China

Correspondence should be addressed to Jianfei Huang; moc.621@rotcodyytn and Xingmei Feng; moc.621@tniemgnixgnef

Received 23 January 2017; Revised 5 April 2017; Accepted 30 April 2017; Published 18 May 2017

Academic Editor: Eric A. Singer

Copyright © 2017 Jun Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recent studies demonstrated high expression of lysosome-associated membrane protein 3 (LAMP3) in a variety of malignancies including esophageal squamous cell carcinoma, gastrointestinal cancer, breast cancer, and cervical cancer and its involvement in several biological activities of tumor cells. However, the expression of LAMP3 and its value in oral squamous cell carcinoma (OSCC) remain unclear. In this study, we examined the expression of LAMP3 in OSCC tissue samples and investigated the relationship between LAMP3 and clinical characteristics of patients with OSCC. We examined mRNA and protein levels of LAMP3 in OSCC tissues and neighboring normal tissues using quantitative real-time polymerase chain reaction and immunohistochemistry analyses, respectively. Both the mRNA and protein levels of LAMP3 were significantly higher in OSCC tissues than in adjacent normal tissues. Chi-square analysis showed that the high LAMP3 expression was notably linked to the degree of tumor differentiation and advanced TNM stage. Univariate and multivariate analyses showed that the high LAMP3 expression was an independent prognostic marker in OSCC. Our results suggest that LAMP3 might act as a potential anticancer target and a prognostic marker in patients with OSCC.