Disease Markers / 2017 / Article / Tab 1 / Review Article
Natriuretic Peptides as Biomarkers for Congestive States: The Cardiorenal Divergence Table 1 Changes in natriuretic peptides in patients treated for acute heart failure.
First author (year) Number of UF patients Age (years) Male gender (%) Decrease in weight (Kg) Fluid removed (liters) Change in BNP (pg/ml) Change in Scr (mg/dL) Costanzo (2005) [29 ] 20 74.5 75 6 8.65 −442 at discharge No significant change (+0.08 at discharge) Costanzo (2007) [30 ] 100 62 70 5 4.6 NA (baseline 1256; similarly improved in both groups) No significant change (+0.3 at 72 hours) Giglioli (2011) [31 ] 15 72.4 87 5.43 9.3 −3266 at 36 hours (NT-proBNP) No significant change (−0.55) at 36 hours Hanna (2012) [32 ] 19 60 84.2 4.7 5.2 −2291 at 48 hours (NT-proBNP) No significant change (+0.2) at 48 hours Bart (2012) [33 ] 94 69 (median) 78 5.7 7.44 −814 at 96 hours (NT-proBNP) +0.23 at 96 hours Jefferies (2013) [34 ] 87 (HFLEF) 97(HFPEF) 65 (HFLEF) 67 (HFPEF) 64 (HFLEF) 46 (HFPEF) 7.57 (HFLEF) 6.39 (HFPEF) 11.14 (HFLEF) 10.6 (HFPEF) −211 (HFLEF) −88 (HFPEF) at discharge +0.22 (HFLEF) no significant change in HFPEF group (+0.9) at discharge Costanzo (2016) [35 ] 110 67 69.1 10.7 at 72 hours 18.7 −250 at discharge +0.12 at discharge
+ and − before a number indicate “increase by” and “decrease by,” respectively. Scr: serum creatinine; NA: not available; HFLEF: heart failure with low ejection fraction; HFPEF: heart failure with preserved ejection fraction; UF: ultrafiltration.