Research Article
Combined Genetic Biomarkers Confer Susceptibility to Risk of Urothelial Bladder Carcinoma in a Saudi Population
Table 3
Genotypic combinations of examined SNPs showing risk of UBC in cases and controls.
| | Genotypic combination | Cases
(%) | Controls
(%) | χ2 ( value | χ2 ( value |
| | GSTM1/GSTT1: | | +,+/+,+ | 36 (34.6) | 112 (53.8) | 10.2 (0.001) | | | −,−/+,+ | 56 (53.8) | 80 (38.5) | 6.6 (0.01) | 10.3 (0.006) | | +,+/−,− | 12 (11.5) | 16 (7.7) | 1.2 (0.3) | | | −,−/−,− | 0 (0.0) | 0 (0.0) | NA | NA | | rs4646903 T>C/ rs1048943 A>G: | | TT/AA | 72 (69.2) | 120 (57.7) | 3.9 (0.04) | | | TC/AG | 8 (7.7) | 24 (11.5) | 1.1 (0.3) | | | TC/AA | 20 (19.2) | 64 (30.8) | 4.7 (0.03) | 13.9 (0.003) | | CC/GG | 4 (3.8) | 0 (0.0) | 4.0 (0.047) | | | rs1801133 C>T/ rs1801394 A>G: | | CC/AA | 0 (0.0) | 8 (3.8) | 4.2 (0.04) | | | CC/AG | 56 (53.8) | 120 (57.7) | 0.4 (0.5) | | | CC/GG | 20 (19.2) | 32 (15.4) | 0.7 (0.4) | | | CT/AA | 0 (0.0) | 8 (3.8) | 4.2 (0.04) | 20.4 (0.0004) | | CT/AG | 20 (19.2) | 40 (19.2) | 0.0 (1.0) | | | CT/GG | 8 (7.7) | 0 (0.0) | 8.3 (0.0001) | |
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“+”: present allele; “−”: null allele; “+,+”: homozygous present genotype; “−,−”: homozygote null genotype; OR: odds ratio; CI: confidence interval.
significant difference between a specific combined genotype in cases and controls.
significant difference between combined genotypes in cases compared with controls.
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