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Disease Markers
Volume 2017 (2017), Article ID 1540949, 7 pages
https://doi.org/10.1155/2017/1540949
Research Article

Relationship between rs854560 PON1 Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease

1Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland
21st Department of Cardiac Surgery/2nd Department of Cardiology, American Heart of Poland, S. A. Armii Krajowej Street 101, 43-316 Bielsko-Biala, Poland
3Department of Internal Medicine, Diabetes and Nephrology, School of Medicine and Division of Dentistry in Zabrze, Medical University of Silesia, 3 Maja Street 13-15, 41-800 Zabrze, Poland
4Regional Center of Blood Donation and Blood Treatment in Racibórz, Sienkiewicza Street 3, 47-400 Racibórz, Poland

Correspondence should be addressed to Joanna Iwanicka

Received 23 June 2017; Revised 25 August 2017; Accepted 14 September 2017; Published 29 September 2017

Academic Editor: Michele Malaguarnera

Copyright © 2017 Joanna Iwanicka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Paraoxonase-1 (PON1) is the antioxidant marker of high-density lipoproteins protecting against atherosclerosis and coronary artery disease (CAD) phenotype. The purpose of the present study was to determine whether the PON1 gene rs854560 polymorphism (163T>A) is associated with CAD in Polish population. rs854560 was genotyped in 494 subjects: 248 patients with premature CAD and 246 blood donors as a control. We found that the risk of CAD was significantly higher in TT homozygotes than in A allele carriers (OR = 1.87, ). The synergistic effect between the TT genotype and cigarette smoking was observed (SIM = 9.81; SI = 14.70). The relative increase in risk from interaction between factors was over 37 (RERI = 36.13). The PON1 polymorphism did not modulate the risk of CAD in response to exposure to other traditional risk factors. In conclusion, the rs854560 polymorphism may modulate the risk of CAD in response to cigarette smoking in Polish population. Carriers of TT genotype seem to be particularly at risk of CAD, when exposed to cigarette smoking.