Relationship between rs854560 PON1 Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease

Table 4

Synergy index (with 95% CI) for interactions between PON1 rs854560 TT genotype and traditional risk factors for CAD.

Traditional risk factors	SIM (95% CI)	SI (95% CI)	RERI (95% CI)	AP (95% CI)
Male gender	0.56 (0.12–2.57)	0.30 (0.02–4.53)	−1.32 (−9.89–1.27)	−0.84 (−7.26–0.53)
Overweight/obesity	2.67 (0.75–9.53)	10.04 (0.06–1568.05)	2.08 (−0.34–6.45)	0.63 (−0.41–0.86)
TC/HDL 5 : 1	0.68 (0.19–2.46)	1.16 (0.35–3.89)	0.71 (−4.18–10.27)	0.12 (−1.74–0.53)
TC (mmol/L)	0.53 (0.15–1.87)	0.86 (0.25–2.98)	−0.47 (−5.39–4.54)	−0.11 (−2.28–0.42)
LDL (mmol/L)	0.34 (0.09–1.24)	0.74 (0.25–2.22)	−1.56 (−9.40–5.04)	−0.29 (−2.66–0.36)
TG (mmol/L)	0.50 (0.14–1.73)	0.74 (0.21–2.60)	−0.92 (−4.98–3.72)	−0.26 (−2.63–0.32)
HDL (mmol/L)	1.10 (0.28–4.36)	1.77 (0.41–7.75)	2.06 (−2.42–13.96)	0.36 (−1.49–0.60)