Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2017, Article ID 1638769, 7 pages
https://doi.org/10.1155/2017/1638769
Research Article

Association between Two Resistin Gene Polymorphisms and Metabolic Syndrome in Jilin, Northeast China: A Case-Control Study

1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China
2Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun, China

Correspondence should be addressed to Changgui Kou; nc.ude.ulj@gcuok

Received 26 July 2017; Revised 17 October 2017; Accepted 30 October 2017; Published 14 December 2017

Academic Editor: Dianjianyi Sun

Copyright © 2017 Yingli Fu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Metabolic syndrome (MetS) is a significant health care problem worldwide and is characterized by increased fasting glucose and obesity. Resistin is a protein hormone produced both by adipocytes and immunocompetent cells, including those residing in adipose tissue, and is believed to modulate glucose tolerance and insulin action. This study examined the association of resistin gene polymorphisms, rs1862513 and rs3745368, and related haplotypes with the development of metabolic syndrome in a Han Chinese population. This case-control study was performed on 3792 subjects, including 1771 MetS cases and 2021 healthy controls from the Jilin province of China. Metabolic syndrome was defined according to the criteria of the International Diabetes Federation (IDF). Logistic regression analysis was used to estimate the relationship between gene polymorphism and MetS. Our results showed that there were no significant associations between MetS and the genotype distributions in four kinds of inheritance models, allele frequencies, and related haplotypes of resistin gene polymorphisms rs1862513 and rs3745368 (all values > 0.05). Based on our study findings, we concluded that mutations in resistin genes are not associated with the presence of MetS in a Han Chinese population from Jilin province in China.