Diagnostic Value of CYFRA 21-1 in the Cerebrospinal Fluid for Leptomeningeal Metastasis

Table 1

Comparison of CSF and serum levels of CEA and CYFRA 21-1 in patients with leptomeningeal metastasis and patients with nonmalignant neurological diseases.

Patients	Tumor markers	Sample	Minimum	25% percentile	Median	75% percentile	Maximum	value
LM	CEA	CSF	≤0.20	4.97	30.74	129.29	2105.00	0.20
	(μg/mL)	Serum	1.29	6.56	17.18	86.76	1118.00
	CYFRA 21-1	CSF	0.50	3.24	6.95	25.73	1180.00	0.00
	(ng/mL)	Serum	0.38	1.81	2.61	4.10	126.20
NMNDs	CEA	CSF	≤0.20	≤0.20	≤0.20	≤0.20	0.23	0.00
	(μg/mL)	Serum	0.45	1.02	1.52	2.08	4.89
	CYFRA 21-1	CSF	0.40	0.66	0.74	0.79	1.01	0.00
	(ng/mL)	Serum	0.85	1.31	1.95	2.36	6.08

LM: leptomeningeal metastasis, NMNDs: nonmalignant neurological diseases.