Diagnostic Value of CYFRA 21-1 in the Cerebrospinal Fluid for Leptomeningeal Metastasis

Table 3

Diagnostic performance of CEA and CYFRA 21-1 in the CSF, CEA, and CYFRA 21-1 in the serum and CSF/serum quotient of CEA and CYFRA 21-1 for differentiating leptomeningeal metastasis from nonmalignant neurological diseases.

Tumor markers		AUC (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)
CEA	CSF	0.98 (0.96–1.00);	0.97 (0.88–0.99)	1.00 (0.93–1.00)
	Serum	0.97 (0.94–1.00);	0.86 (0.74–0.94)	0.97 (0.87–0.99)
	CSF/serum quotient	0.87 (0.80-0.95);	0.72 (0.58–0.82)	0.970 (0.79–0.96)
CYFRA 21-1	CSF	0.97 (0.93–1.00);	0.97 (0.88–0.99)	1.00 (0.93–1.00)
	Serum	0.67 (0.58–0.77);	0.50 (0.41–0.59)	0.83 (0.71–0.91)
	CSF/serum quotient	0.93 (0.87–0.99);	0.88 (0.77–0.95)	0.97 (0.87–0.99)