Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2017, Article ID 2594231, 7 pages
https://doi.org/10.1155/2017/2594231
Research Article

Local and Systemic Immune Responses to Influenza A Virus Infection in Pneumonia and Encephalitis Mouse Models

Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Correspondence should be addressed to Hirokazu Tsukahara; pj.ca.u-amayako.cc@h-hakust

Received 8 May 2017; Revised 7 July 2017; Accepted 27 July 2017; Published 24 August 2017

Academic Editor: Hubertus Himmerich

Copyright © 2017 Yoshiharu Nagaoka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Q. Liu, Y. H. Zhou, and Z. Q. Yang, “The cytokine storm of severe influenza and development of immunomodulatory therapy,” Cellular & Molecular Immunology, vol. 13, no. 1, pp. 3–10, 2016. View at Publisher · View at Google Scholar · View at Scopus
  2. M. D. de Jong, C. P. Simmons, T. T. Thanh et al., “Fatal outcome of human influenza a (H5N1) is associated with high viral load and hypercytokinemia,” Nature Medicine, vol. 12, no. 10, pp. 1203–1207, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Sato, M. Hosoya, and P. F. Wright, “Differences in serum cytokine levels between influenza virus A and B infections in children,” Cytokine, vol. 47, no. 1, pp. 65–68, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. K. K. To, I. F. Hung, I. W. Li et al., “Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection,” Clinical Infectious Diseases, vol. 50, no. 6, pp. 850–859, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Hagau, A. Slavcovici, D. N. Gonganau et al., “Clinical aspects and cytokine response in severe H1N1 influenza A virus infection,” Critical Care, vol. 14, no. 6, article R203, 2010. View at Publisher · View at Google Scholar
  6. N. Lee, C. K. Wong, P. K. Chan et al., “Cytokine response patterns in severe pandemic 2009 H1N1 and seasonal influenza among hospitalized adults,” PLoS One, vol. 6, no. 10, article e26050, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Guo, F. Huang, J. Liu et al., “The serum profile of hypercytokinemia factors identified in H7N9-infected patients can predict fatal outcomes,” Scientific Reports, vol. 5, article 10942, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Kawada, H. Kimura, Y. Ito et al., “Systemic cytokine responses in patients with influenza-associated encephalopathy,” The Journal of Infectious Diseases, vol. 188, no. 5, pp. 690–698, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Hosoya, H. Nunoi, M. Aoyama, Y. Kawasaki, and H. Suzuki, “Cytochrome c and tumor necrosis factor-alpha values in serum and cerebrospinal fluid of patients with influenza-associated encephalopathy,” The Pediatric Infectious Disease Journal, vol. 24, no. 5, pp. 467–470, 2005. View at Google Scholar
  10. Y. Ito, Y. Torii, R. Ohta et al., “Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenza-infected children,” Cytokine, vol. 56, no. 2, pp. 180–187, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Hasegawa, T. Matsushige, H. Inoue, K. Shirabe, R. Fukano, and T. Ichiyama, “Serum and cerebrospinal fluid cytokine profile of patients with 2009 pandemic H1N1 influenza virus-associated encephalopathy,” Cytokine, vol. 54, no. 2, pp. 167–172, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Garcia-Sastre, R. K. Durbin, H. Zheng et al., “The role of interferon in influenza virus tissue tropism,” Journal of Virology, vol. 72, no. 11, pp. 8550–8558, 1998. View at Google Scholar
  13. K. E. Wolk, E. R. Lazarowski, Z. P. Traylor et al., “Influenza A virus inhibits alveolar fluid clearance in BALB/c mice,” American Journal of Respiratory and Critical Care Medicine, vol. 178, no. 9, pp. 969–976, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. P. G. Stevenson, S. Freeman, C. R. Bangham, and S. Hawke, “Virus dissemination through the brain parenchyma without immunologic control,” Journal of Immunology, vol. 159, no. 4, pp. 1876–1884, 1997. View at Google Scholar
  15. N. Nosaka, M. Yashiro, M. Yamada et al., “Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice,” Critical Care, vol. 19, no. 1, p. 249, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. M. S. Yang, E. J. Park, S. Sohn et al., “Interleukin-13 and -4 induce death of activated microglia,” Glia, vol. 38, no. 4, pp. 273–280, 2002. View at Google Scholar
  17. S. Morichi, H. Kawashima, H. Ioi, G. Yamanaka, Y. Kashiwagi, and A. Hoshika, “High production of interleukin-10 and interferon-gamma in influenza-associated MERS in the early phase,” Pediatrics International, vol. 54, no. 4, pp. 536–538, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. S. S. Puntambekar, D. R. Hinton, X. Yin et al., “Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination,” Glia, vol. 63, no. 11, pp. 2106–2120, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Y. Niederkorn, “See no evil, hear no evil, do no evil: the lessons of immune privilege,” Nature Immunology, vol. 7, no. 4, pp. 354–359, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. V. A. Arankalle, K. S. Lole, R. P. Arya et al., “Role of host immune response and viral load in the differential outcome of pandemic H1N1 (2009) influenza virus infection in Indian patients,” PLoS One, vol. 5, no. 10, article e13099, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Zuniga, M. Torres, J. Romo et al., “Inflammatory profiles in severe pneumonia associated with the pandemic influenza A/H1N1 virus isolated in Mexico City,” Autoimmunity, vol. 44, no. 7, pp. 562–570, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Aiba, M. Mochizuki, M. Kimura, and H. Hojo, “Predictive value of serum interleukin-6 level in influenza virus-associated encephalopathy,” Neurology, vol. 57, no. 2, pp. 295–299, 2001. View at Google Scholar
  23. T. Ichiyama, T. Morishima, H. Isumi, H. Matsufuji, T. Matsubara, and S. Furukawa, “Analysis of cytokine levels and NF-kappaB activation in peripheral blood mononuclear cells in influenza virus-associated encephalopathy,” Cytokine, vol. 27, no. 1, pp. 31–37, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Momonaka, S. Hasegawa, T. Matsushige et al., “High mobility group box 1 in patients with 2009 pandemic H1N1 influenza-associated encephalopathy,” Brain and Development, vol. 36, no. 6, pp. 484–488, 2014. View at Publisher · View at Google Scholar · View at Scopus