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Disease Markers
Volume 2017, Article ID 3062759, 7 pages
https://doi.org/10.1155/2017/3062759
Research Article

Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese Han Population

1School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China
2Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China
3Department of Nephrology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China
4Futian District Chronic Disease Prevention and Cure Center, Shenzhen, China

Correspondence should be addressed to Lei Shi; moc.361@129226ihsycul and Shujin Zhao; moc.361@shzjszzg

Received 25 March 2017; Revised 23 May 2017; Accepted 25 May 2017; Published 18 July 2017

Academic Editor: Zhongjie Shi

Copyright © 2017 Jin Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Hypertension, including essential and secondary hypertension, is a multifactorial disease, affecting more than one billion people worldwide. Secondary hypertension can result from mutations of cullin-3 (CUL3); however, whether polymorphisms of CUL3 are associated with essential hypertension (EH) has not been reported. Here, we investigated the association between CUL3 SNPs rs17479770 and rs3738952 and EH in the Chinese Han population. Methods. This case-control study investigated 520 representatives, including 259 patients with EH and 261 normotensive controls matched for age, gender, BMI, TG, TC, and HbA1c for the distribution of functional rs17479770 and rs3738952 within the CUL3 gene by using PCR and RFLP. Results. Our results showed that there was no significant difference in allele and genotype distribution of rs3738952 and haplotype distribution of rs17479770 and rs3738952 between the EH group and normotensive group, whereas the rs17479770 TT genotype in male and the full data set were significantly associated with the decreased risk of EH (, ), and rs17479770 allele T in male was shown to have the correlation tendency of the decreased risk of EH (). Conclusion. Our data suggest that the CUL3 rs17479770 variant could be a protective factor in the pathogenesis of EH.