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Disease Markers
Volume 2017, Article ID 3064246, 11 pages
Research Article

The Prognostic Value of Decreased KLF4 in Digestive System Cancers: A Meta-Analysis from 17 Studies

1Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
2Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Correspondence should be addressed to Chaodong Liu; moc.361@55306203331

Received 10 April 2017; Revised 19 July 2017; Accepted 20 August 2017; Published 14 September 2017

Academic Editor: Benoit Dugue

Copyright © 2017 Jianpei Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The prognostic value of loss of Krüppel-like factor 4 (KLF4) expression in digestive system cancers has not reached a consensus. This study aimed for a comprehensive investigation of the internal associations between KLF4 expression loss and prognostic implications in patients with digestive system cancers. Methods. We searched for all relevant literatures in the electronic databases until February 1, 2017. The degree of association between KLF4 and prognosis was evaluated by pooled hazard ratios (HRs) as well as relevant 95% confidence intervals (95% CIs). Results. Seventeen eligible studies with 2118 patients revealed that loss of KLF4 expression was connected with poor prognosis, with the pooled HRs of 1.61 (95% CI: 1.17–2.20, ) for the overall survival (OS) and 1.99 (95% CI: 1.12–3.52, ) for the disease-free survival (DFS)/recurrence-free survival (RFS)/metastasis-free survival (MFS). Additionally, loss of KLF4 expression was also related to a worse disease-special survival (DSS) yielding a pooled HR of 1.73 (95% CI: 1.08–2.77, ). Conclusion. Our findings suggest that loss of KLF4 expression is correlated with a bad outcome in most digestive system cancers, apart from esophagus squamous cell carcinoma (ESCC).