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Disease Markers
Volume 2017 (2017), Article ID 4191365, 10 pages
https://doi.org/10.1155/2017/4191365
Research Article

Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population

1Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China
2West China School of Medicine/West China Hospital of Sichuan University, Chengdu 610041, China
3Laboratory of Molecular Translational Medicine, Key Laboratory of Obstetric & Gynecology and Pediatric Diseases and Birth Defects of Ministry of Education, West China Institute of Women’s and Children’s Health/West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

Correspondence should be addressed to Li Rao

Received 22 January 2017; Revised 4 March 2017; Accepted 28 March 2017; Published 10 May 2017

Academic Editor: Agata M. Bielecka-Dabrowa

Copyright © 2017 Huizi Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To explore the role of Interkeulin-31 (IL-31) in dilated cardiomyopathy (DCM), in our study, two SNPs of IL-31, rs4758680 (C/A) and rs7977932 (C/G), were analyzed in 331 DCM patients and 493 controls in a Chinese Han population. The frequencies of C allele and CC genotype of rs4758680 were significantly increased in DCM patients (, , resp.). Compared to CC genotype of rs4758680, the A carriers (CA/AA genotypes) were the protect factors in DCM susceptibility while the frequencies of CA/AA genotypes were decreased in the dominant model for DCM group (, OR = 0.56, 95%CI = 0.39–0.79). Moreover, IL-31 mRNA expression level of white blood cells was increased in DCM patients (0.072 (0.044–0.144) versus 0.036 (0.020–0.052), ). In survival analysis of 159 DCM patients, Kaplan-Meier curve revealed the correlation between CC homozygote of rs4758680 and worse prognosis for DCM group (). Compared to CC genotype, the CA/AA genotypes were the independent factors in both univariate (HR = 0.530, 95%CI = 0.337–0.834, ) and multivariate analyses after age, gender, left ventricular end-diastolic diameter, and left ventricular ejection fraction adjusted (HR = 0.548, 95%CI = 0.345–0.869, ). Thus, we concluded that IL-31 gene polymorphisms were tightly associated with DCM susceptibility and contributed to worse prognosis in DCM patients.