Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population

Table 3

Distributions of IL-31 SNPs among cases and controls and their associations with DCM susceptibility.

	Genotype	rs4758680				Genotype	rs7977932
		Cases; n (%)	Controls; n (%)	OR (95%CI)	value		Cases; n (%)	Controls; n (%)	OR (95%CI)	value
Model
Codominant	CC	275 (83.1%)	361 (73.2%)	1.00	—	CC	271 (81.9%)	401 (81.3%)	1.00	—
	CA	43 (13.0%)	114 (23.1%)	0.50 (0.34–0.72)	0.001	CG	56 (16.9%)	87 (17.6%)	1.05 (0.73–1.52)	0.930
	AA	13 (3.9%)	18 (3.6%)	0.95 (0.46–1.96)	—	GG	4 (1.2%)	5 (1.0%)	0.84 (0.22–3.17)	—
Dominant	CC	275 (83.1%)	361 (73.2%)	1.00	—	CC	271 (81.9%)	401 (81.3%)	1.00	—
	CA/AA	56 (16.9%)	132 (26.8%)	0.56 (0.39–0.79)	<0.001	CG/GG	60 (18.1%)	92 (18.7%)	1.04 (0.72–1.49)	0.850
Recessive	CC/CA	318 (96.1%)	475 (96.3%)	1.00	—	CC/CG	327 (98.8%)	488 (99.0%)	1.00	—
	AA	13 (3.9%)	18 (3.6%)	0.93 (0.45–1.92)	0.840	GG	4 (1.2%)	5 (1.0%)	0.84 (0.22–3.14)	0.790
Overdominant	CC/AA	288 (87.0%)	379 (76.9%)	1.00	—	CC/GG	275 (83.1%)	406 (82.4%)	1.00	—
	CA	43 (13.0%)	114 (23.1%)	0.50 (0.34–0.73)	<0.001	CG	56 (16.9%)	87 (17.6%)	1.05 (0.73–1.52)	0.790
	Allele					Allele
	C	593 (89.6%)	836 (84.8%)	1.00	—	C	598 (90.3%)	889 (90.2%)	1.00	—
	A	69 (10.4%)	150 (15.2%)	0.65 (0.48–0.88)	0.005	G	64 (9.7%)	97 (9.8%)	1.02 (0.73–1.42)	0.909

OR: odds ratio; CI: confidence interval; SNP analysis adjusted for age, gender, LVEDD, and LVEF.