Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population

Table 2

Odds ratios (ORs) and 95% confidence intervals (CIs) for GCLM (-588C/T) and GCLC (-129T/C) genes in studied general mixed groups.

Gene polymorphism	Genotype	Controls	IHD patients	OR (95% CI)	value
GCLM (-588C/T)	CC	250	229	0.64 (0.46–0.88)	0.009
	CT	87	119	1.44 (1.04–2.00)
	TT	4	12	2.91 (0.93–9.10)
GCLM (-588C/T) dominant model	CC + CT	337	348	0.34 (0.11–1.08)	0.05
	TT	4	12	2.91 (0.93–9.10)
GCLM (-588C/T) receive model	CC	250	229	0.64 (0.46–0.88)	0.006
	CT + TT	91	131	1.57 (1.14–2.17)
GCLC (-129T/C)	CC	268	257	0.68 (0.48–0.96)	0.03
	CT	70	93	1.35 (0.95–1.92)
	TT	3	10	3.22 (0.88–11.80)
GCLC (-129T/C) dominant model	CC + CT	338	350	0.31 (0.08–1.14)	0.06
	TT	3	10	3.22 (0.88–11.80)
GCLC (-129T/C) receive model	CC	268	257	0.68 (048–0.96)	0.03
	CT + TT	73	103	1.47 (1.04–2.08)