Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population

Table 3

Odds ratios (ORs) and 95% confidence intervals (CIs) for GCLM (-588C/T) and GCLC (-129T/C) genes based on Kazakh and Russian ethnicity (general inheritance model).

Groups	Genotypes	Case/control, n	OR (95% CI)		value
GCLM -588C/T
Ethnicity
Kazakh	CC	156/180	0.67 (0.44–1.00)	6.211	0.04
	CT	66/55	1.33 (0.88–2.02)
	TT	8/2	4.23 (0.89–20.16)
Russian	CC	60/48	0.68 (0.36–1.29)	1.388	0.5
	CT	38/21	1.41 (0.74–2.70)
	TT	4/2	1.41 (0.25–7.90)
GCLC -129T/C
Kazakh	CC	168/191	0.65 (0.42–1.01)	6.660	0.04
	CT	53/44	1.31 (0.84–2.06)
	TT	9/2	4.79 (1.02–22.39)
Russian	CC	66/49	0.82 (0.43–1.57)	0.473	0.8
	CT	35/21	1.24 (0.65–2.39)
	TT	1/1	0.69 (0.04–11.27)