Polymorphisms in the SP110 and TNF-α Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population
Table 3
The frequencies of polymorphisms in TNF-α gene and association analyses with the risk of PTB and STB.
SNPs
Genotype /allele
PTB (%)
STB (%)
Controls (%)
PTB versus controls
STB versus controls
STB versus PTB
()
()
()
Pa
OR [95% CI]a
Pa
OR [95% CI]a
Pa
OR [95% CI]a
TNF-a -308G>A (rs1800629)
Genotype
AA
0 (0)
0 (0)
2 (0.6)
NA
NA
NA
AG
17 (8.9)
13 (7.1)
27 (7.5)
0.673
1.151 [0.599–2.211]
0.840
0.931 [0.468–1.854]
0.660
0.841 [0.389–1.818]
GG
173 (91.1)
170 (92.9)
333 (92.0)
Ref
Ref
Ref
Allele
A
17 (4.5)
13 (3.6)
31 (4.3)
1.000
1.000 [0.537–1.863]
0.547
0.816 [0.421–1.581]
0.540
0.789 [0.370–1.684]
G
363 (95.5)
353 (96.4)
693 (95.7)
Ref
Ref
Ref
Dominant model
AA + AG
17 (8.9)
13 (7.1)
29 (8.0)
0.840
1.069 [0.561–2.037]
0.677
0.865 [0.438–1.710]
0.660
0.841 [0.389–1.818]
GG
173 (91.1)
170 (92.9)
333 (92.0)
Ref
Ref
Ref
Recessive model
AA
0 (0)
0 (0)
2 (0.6)
NA
NA
NA
AG + GG
190 (100.0)
183 (100.0)
360 (99.4)
Ref
Ref
Ref
TNF-a -238G>A (rs361525)
Genotype
AA
0 (0)
0 (0)
1 (0.3)
NA
NA
NA
AG
12 (6.3)
4 (2.2)
20 (5.5)
0.842
0.925 [0.430–1.987]
0.062∗
0.352 [0.118–1.053]
0.140
0.414 [0.128–1.337]
GG
178 (93.7)
179 (97.8)
341 (94.2)
Ref
Ref
Ref
Allele
A
12 (3.2)
4 (1.1)
22 (3.0)
0.589
0.817 [0.392–1.701]
0.044†
0.331 [0.113–0.972]
0.182
0.456 [0.144–1.445]
G
368 (96.8)
362 (98.9)
702 (97.0)
Ref
Ref
Ref
Dominant model
AA + AG
12 (6.3)
4 (2.2)
21 (5.8)
0.725
0.873 [0.409–1.861]
0.050∗
0.335 [0.113–0.999]
0.140
0.414 [0.128–1.337]
GG
178 (93.7)
179 (97.8)
341 (94.2)
Ref
Ref
Ref
Recessive model
AA
0 (0)
0 (0)
1 (0.3)
NA
NA
NA
AG + GG
190 (100.0)
183 (100.0)
361 (99.7)
Ref
Ref
Ref
PTB: pulmonary tuberculosis; STB: spinal tuberculosis; OR: odds ratio; CI: confidence interval; Ref: reference; SNP: single-nucleotide polymorphism; NA: not calculated as zero count in at least one cell of the two by two table. aThe estimated odds ratios (ORs) and relative 95% confidence intervals (95% CI) were adjusted for age and gender. ∗ and ; the changes were considered as trends. .
