Research Article
Polymorphisms in the SP110 and TNF-α Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population
Table 4
The frequencies of polymorphisms in SP110 gene and association analyses with the risk of PTB and STB.
| | SNPs | Genotype /Allele | PTB (%) | STB (%) | Controls (%) | PTB versus Controls | STB versus Controls | STB versus PTB | | () | () | () | Pa | OR [95% CI]a | Pa | OR [95% CI]a | Pa | OR [95% CI]a |
| | SP110 rs722555 | | Genotype | AA | 39 (20.5) | 28 (15.3) | 60 (16.6) | 0.245 | 1.364 [0.808–2.305] | 0.784 | 0.927 [0.538–1.597] | 0.235 | 0.688 [0.372–1.276] | | AG | 95 (50.0) | 93 (50.8) | 176 (48.6) | 0.403 | 1.191 [0.790–1.797] | 0.743 | 1.068 [0.719–1.586] | 0.690 | 0.909 [0.568–1.453] | | GG | 56 (29.5) | 62 (33.9) | 126 (34.8) | | Ref | | Ref | | Ref |
| | Allele | A | 173 (45.5) | 149 (40.7) | 296 (40.9) | 0.227 | 1.171 [0.906–1.514] | 0.894 | 0.983 [0.760–1.270] | 0.261 | 0.844 [0.628–1.135] | | G | 207 (54.5) | 217 (59.3) | 428 (59.1) | | Ref | | Ref | | Ref |
| | Dominant model | AA + AG | 134 (70.5) | 121 (66.1) | 236 (65.2) | 0.282 | 1.237 [0.839–1.825] | 0.868 | 1.032 [0.709–1.503] | 0.461 | 0.845 [0.542–1.321] | | GG | 56 (29.5) | 62 (33.9) | 126 (34.8) | | Ref | | Ref | | Ref |
| | Recessive model | AA | 39 (20.5) | 28 (15.3) | 60 (16.6) | 0.384 | 1.227 [0.775–1.943] | 0.646 | 0.891 [0.546–1.455] | 0.258 | 0.730 [0.424–1.259] | | AG + GG | 151 (79.5) | 155 (84.7) | 302 (83.4) | | Ref | | Ref | | Ref |
| | SP110 rs1135791 | | Genotype | CC | 7 (3.7) | 5 (2.7) | 10 (2.8) | 0.683 | 1.235 [0.449–3.397] | 0.958 | 0.971 [0.324–2.913] | 0.614 | 0.735 [0.223–2.427] | | CT | 54 (28.4) | 49 (26.8) | 89 (24.6) | 0.205 | 1.303 [0.866–1.960] | 0.532 | 1.139 [0.757–1.714] | 0.635 | 0.893 [0.561–1.425] | | TT | 129 (67.9) | 129 (70.5) | 263 (72.7) | | Ref | | Ref | | Ref |
| | Allele | C | 68 (17.9) | 59 (16.1) | 109 (15.1) | 0.219 | 1.238 [0.881–1.740] | 0.644 | 1.085 [0.768–1.533] | 0.506 | 0.876 [0.593–1.294] | | T | 312 (82.1) | 307 (83.9) | 615 (84.9) | | Ref | | Ref | | Ref |
| | Dominant model | CC + CT | 61 (32.1) | 54 (29.5) | 99 (27.3) | 0.194 | 1.296 [0.876–1.919] | 0.568 | 1.122 [0.757–1.663] | 0.561 | 0.876 [0.559–1.372] | | TT | 129 (67.9) | 129 (70.5) | 263 (72.7) | | Ref | | Ref | | Ref |
| | Recessive model | CC | 7 (3.7) | 5 (2.7) | 10 (2.8) | 0.785 | 1.150 [0.421–3.145] | 0.910 | 0.939 [0.315–2.801] | 0.649 | 0.759 [0.232–2.488] | | CT + TT | 183 (96.3) | 178 (97.3) | 352 (97.2) | | Ref | | Ref | | Ref |
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PTB: pulmonary tuberculosis; STB: spinal tuberculosis; OR: odds ratio; CI: confidence interval; Ref: reference; SNP: single-nucleotide polymorphism. aThe estimated odds ratios (ORs) and relative 95% confidence intervals (95% CI) were adjusted for age and gender.
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