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Disease Markers
Volume 2017 (2017), Article ID 4731891, 9 pages
https://doi.org/10.1155/2017/4731891
Research Article

Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

1Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province 130021, China
2Maternal and Child Health Center of Chaoyang District, Beijing 100020, China
3Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun 130021, China

Correspondence should be addressed to Xueyuan Cao; moc.nuyila@yxoac and Jing Jiang; nc.ude.ulj@00020791gnijgnaij

Received 7 November 2016; Revised 28 December 2016; Accepted 16 January 2017; Published 19 February 2017

Academic Editor: Marco E. M. Peluso

Copyright © 2017 Yanhua Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility. Secondly, among the 897 GC patients above, 755 cases underwent a radical operation, without distant metastasis and with negative surgical margins included in the survival analysis to evaluate the association of the four SNPs above with gastric cancer prognosis. The C/T or C/C genotypes of rs213210 were related to a lower GC risk (OR = 0.76, 95% CI: 0.62–0.93, ) compared to the T/T genotype. Rs11134527 in miR-218 was associated with GC survival, and the G/A and G/G genotypes of rs11134527 resulted in a decreased risk of death when compared with the A/A genotype (HR = 0.75, 95% CI: 0.61–0.95, ). This study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis.