The Predictive Value of PITX2 DNA Methylation for High-Risk Breast Cancer Therapy: Current Guidelines, Medical Needs, and Challenges

Table 1

Traditional classification of breast cancer subgroups.

Classification	Expression	Distribution (%)
Luminal A	ER/PR+, HER2−	~65
Luminal B	ER/PR+, HER2+/−	~15
HER2-type	ER/PR−, HER2+	~5
Triple-negative	ER/PR−, HER2−	~15

According to [3, 5, 8] (http://ww5.komen.org/BreastCancer/SubtypesofBreastCancer.html).