The Predictive Value of PITX2 DNA Methylation for High-Risk Breast Cancer Therapy: Current Guidelines, Medical Needs, and Challenges

Table 4

Subclassification of TNBC based on gene expression analysis.

Characteristics
BL1 (basal-like 1)	Increased expression of cell cycle and DNA repair genes
BL2 (basal-like 2)	Increased expression of growth factor signaling and myoepithelial markers
M	Increased expression of genes involved in epithelial-mesenchymal-like transition and growth factor pathways
MSL	Decreased expression of genes involved in proliferation (mesenchymal stem cell-like)
IM	Immune cell processes, expression of genes involved in cytokine signal immunomodulatory transduction pathway
LAR	Luminal gene expression and androgen receptor signaling genes

According to Lehmann et al. [33] and Szekely et al. [13].