Review Article
The Predictive Value of PITX2 DNA Methylation for High-Risk Breast Cancer Therapy: Current Guidelines, Medical Needs, and Challenges
Table 4
Subclassification of TNBC based on gene expression analysis.
| Characteristics |
| BL1 (basal-like 1) | Increased expression of cell cycle and DNA repair genes | BL2 (basal-like 2) | Increased expression of growth factor signaling and myoepithelial markers | M | Increased expression of genes involved in epithelial-mesenchymal-like transition and growth factor pathways | MSL | Decreased expression of genes involved in proliferation (mesenchymal stem cell-like) | IM | Immune cell processes, expression of genes involved in cytokine signal immunomodulatory transduction pathway | LAR | Luminal gene expression and androgen receptor signaling genes |
|
|
According to Lehmann et al. [33] and Szekely et al. [13].
|