Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis

Table 3

Uni- and multivariate Cox regression analyses for GDF-15 levels at ICU admission to predict ICU mortality.

	All patients				Sepsis patients
	Unadjusted HR (95% CI)		Adjusted HR (95% CI)		Unadjusted HR (95% CI)		Adjusted HR (95% CI)
GDF-15 > 3624 pg/mL	4.41 (1.74–11.17)	0.009	3.42 (1.33–8.78)	0.027	3.75 (1.33–10.58)	0.012	3.16 (1.10–9.07)	0.033
Creatinine	—	n.s.	—	n.s.	0.99 (0.97–1.02)	0.046	—	n.s.
CRP	—	n.s.	—	n.s.	—	n.s.	—	n.s.
Bilirubin	—	n.s.	—	n.s.	—	n.s.	—	n.s.
Prothrombin time	—	n.s.	—	n.s.	—	n.s.	—	n.s.
Lactate	1.11 (1.03–1.20)	0.008	1.13 (1.05–1.22)	0.002	1.15 (1.07–1.24)	<0.001	1.12 (1.04–1.22)	0.005
Age	1.03 (1.01–1.05)	0.006	1.03 (1.01–1.05)	0.009	—	n.s.	—	0.009

95% CI: 95% confidence interval; CRP: C-reactive protein; GDF-15: growth differentiation factor-15.