Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis

Table 4

Uni- and multivariate Cox regression analyses for GDF-15 levels at ICU admission to predict overall mortality.

	All patients				Sepsis patients
	Unadjusted HR (95% CI)		Adjusted HR (95% CI)		Unadjusted HR (95% CI)		Adjusted HR (95% CI)
GDF-15> 3884 pg/mL	3.03 (1.63–5.66)	0.005	2.0 (1.02-3.88)	0.041	3.93 (1.66–9.33)	0.002	2.61 (1.14–6.02)	0.033
Creatinine	—	n.s.	—	n.s.	—	n.s.	—	n.s.
CRP	—	n.s.	—	n.s.	—	n.s.	—	n.s.
Bilirubin	1.20 (1.03–1.40)	0.023	—	n.s.	—	n.s.	—	n.s.
Prothrombin time	0.99 (0.98–0.99)	0.037	—	n.s.	—	n.s.	—	n.s.
Lactate	—	n.s.	—	n.s.	1.21 (1.01–1.45)	0.04	—	n.s.
Age	1.03 (1.01–1-05)	0.004	1.028 (1.01–1.05)	0.017	1.03 (1.01–1.06)	0.008	—	n.s.

95% CI: 95% confidence interval; CRP: C-reactive protein; GDF-15: growth differentiation factor-15.