Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes
Table 2
Correlation between circulating cathepsin D levels and clinical parameters.
Variables
All subjects ()
Control ()
Case ()
Coefficient
value
Coefficient
value
Coefficient
value
Age (years)
−0.01
0.87
−0.01
0.90
−0.02
0.85
BMI (kg/m2)
0.19
0.01
0.10
0.31
0.12
0.23
Systolic BP (mmHg)
0.08
0.27
0.05
0.60
0.01
0.97
Diastolic BP (mmHg)
0.04
0.61
−0.03
0.74
−0.01
0.97
Total cholesterol (mmol/l)
0.07
0.33
0.04
0.69
0.02
0.86
Triglyceride (mmol/l)
0.18
0.01
0.17
0.10
0.15
0.15
LDL cholesterol (mmol/l)
0.04
0.60
0.12
0.25
−0.15
0.15
HDL cholesterol (mmol/l)
−0.02
0.74
0.06
0.56
−0.07
0.50
HbA1c (%)
0.16
0.02
−0.04
0.69
0.02
0.86
Fasting glucose (mmol/l)
0.26
<0.01
−0.01
0.99
0.19
0.06
HOMA-IR
0.29
<0.01
0.02
0.33
0.25
0.01
HOMA-IS
0.09
0.22
0.13
0.19
0.02
0.84
Circulating cathepsin D levels were log-transformed variable. BMI: body mass index; BP: blood pressure; HbA1c: hemoglobin A1c; LDL: low-density lipoprotein; HDL: high-density lipoprotein; HOMA-IR: homeostasis model assessment of insulin resistance; HOMA-IS: homeostasis model assessment of insulin secretion.
