Research Article
Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity
Table 2
Genotype and allele frequencies of control and case individuals and association with the risk of obesity.
| | Genes | Polymorphism | Case | Control | OR (95% CI) | P | P¥ | | (%) | (%) |
| | ADIPOQ | rs182052 | | | | Genotype | GG | 61 (36.5) | 80 (48.5) | 1.00 (Ref.) | — | — | | GA | 82 (49.1) | 73 (44.2) | 1.47 (0.93–2.32) | 0.098 | 0.179 | | AA | 24 (14.4) | 12 (7.3) | 2.57 (1.22–5.42) | 0.014 | 0.023 | | Dominant model | | | GG | 61 (36.5) | 80 (48.5) | 1.00 (Ref.) | — | — | | GA + AA | 106 (63.5) | 85 (51.5) | 1.63 (1.05–2.52) | 0.028 | 0.061 | | Recessive model | | | GG + GA | 143 (85.6) | 153 (92.7) | 1.00 (Ref.) | — | — | | AA | 24 (14.4) | 12 (7.3) | 2.14 (1.03-4.44) | 0.041 | 0.049 | | Allele | G | 204 (61.1) | 233 (70.6) | 1.00 (Ref.) | — | — | | A | 130 (38.9) | 97 (29.4) | 1.56 (1.12–2.19) | 0.009 | 0.020 |
| | RARRES2 | rs17173608 | | | | Genotype | TT | 140 (83.8) | 137 (83.0) | 1.00 (Ref.) | — | — | | TG | 24 (14.4) | 27 (16.4) | 0.87 (0.48–1.58) | 0.648 | 0.191 | | GG | 3 (1.8) | 1 (0.6) | 2.94 (0.30–28.57) | 0.354 | 0.483 | | Dominant model | | | TT | 140 (83.8) | 137 (83.0) | 1.00 (Ref.) | — | — | | TG + GG | 27 (16.2) | 28 (17.0) | 0.94 (0.53–1.68) | 0.844 | 0.272 | | Recessive model | | | TT + TG | 164 (98.2) | 164 (99.4) | 1.00 (Ref.) | — | — | | GG | 3 (1.8) | 1 (0.6) | 3.00 (0.31–29.14) | 0.344 | 0.364 | | Allele | T | 304 (91.0) | 301 (91.2) | 1.00 (Ref.) | — | — | | G | 30 (9.0) | 29 (8.8) | 1.02 (0.61–1.72) | 0.932 | 0.420 | | rs4721 | | | | Genotype | TT | 43 (25.7) | 56 (33.9) | 1.00 (Ref.) | — | — | | TG | 91 (54.5) | 81 (49.1) | 1.46 (0.89–2.41) | 0.134 | 0.405 | | GG | 33 (19.8) | 28 (17.0) | 1.54 (0.81–2.92) | 0.190 | 0.873 | | Dominant model | | | TT | 43 (25.7) | 56 (33.9) | 1.00 (Ref.) | — | — | | TG + GG | 124 (74.3) | 109 (66.1) | 1.48 (0.92–2.38) | 0.104 | 0.481 | | Recessive model | | | TT + TG | 134 (80.2) | 137 (83.0) | 1.00 (Ref.) | — | — | | GG | 33 (19.8) | 28 (17.0) | 1.21 (0.69–2.10) | 0.512 | 0.774 | | Allele | T | 177 (53.0) | 183 (57.2) | 1.00 (Ref.) | — | — | | G | 157 (47.0) | 137 (42.8) | 1.26 (0.92–1.74) | 0.145 | 0.756 |
| | PGC1a | rs8192678 | | | | Genotype | GG | 91 (54.5) | 84 (50.9) | 1.00 (Ref.) | — | — | | GA | 62 (37.1) | 71 (43.0) | 0.81 (0.51–1.27) | 0.350 | 0.519 | | AA | 14 (8.4) | 10 (6.1) | 1.29 (0.55–3.01) | 0.561 | 0.681 | | Dominant model | | | GG | 91 (54.5) | 84 (50.9) | 1.00 (Ref.) | — | — | | GA + AA | 76 (45.5) | 81 (49.1) | 0.87 (0.56–1.33) | 0.513 | 0.657 | | Recessive model | | | GG + GA | 153 (91.6) | 155 (93.9) | 1.00 (Ref.) | — | — | | AA | 14 (8.4) | 10 (6.1) | 1.41 (0.61–3.29) | 0.416 | 0.566 | | Allele | G | 244 (73.1) | 239 (72.4) | 1.00 (Ref.) | — | — | | A | 90 (26.9) | 91 (27.6) | 0.97 (0.69–1.37) | 0.855 | 0.978 | | rs3736265 | | | | Genotype | GG | 151 (87.3) | 144 (90.4) | 1.00 (Ref.) | — | — | | GA | 15 (11.5) | 19 (9.0) | 0.75 (0.37–1.54) | 0.436 | 0.674 | | AA | 1 (1.2) | 2 (0.6) | 0.48 (0.04–5.32) | 0.547 | 0.163 | | Dominant model | | | GG | 151 (90.4) | 144 (87.3) | 1.00 (Ref.) | — | — | | GA + AA | 16 (9.6) | 21 (12.7) | 0.73 (0.37–1.45) | 0.364 | 0.460 | | Recessive model | | | GG + GA | 166 (99.4) | 163 (98.8) | 1.00 (Ref.) | — | — | | AA | 1 (0.6) | 2 (1.2) | 0.49 (0.44–5.47) | 0.563 | 0.166 | | Allele | G | 317 (94.9) | 307 (93.0) | 1.00 (Ref.) | — | — | | A | 17 (7.0) | 23 (5.1) | 0.74 (0.40–1.37) | 0.333 | 0.312 |
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values for logistic regression. ¥ values adjusted for gender and age.
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