Serum Autoantibodies against STIP1 as a Potential Biomarker in the Diagnosis of Esophageal Squamous Cell Carcinoma

Table 1

Participant details and clinicopathological features.

Group	Training cohort		Validation cohort
	ESCC ()	Normal ()	ESCC ()	Normal ()
Age, years
Mean ± SD	58 ± 9	57 ± 8	59 ± 6	56 ± 7
Range	41–88	38–77	43–75	40–71
Gender
Male	114	69	38	26
Female	34	25	22	14
Smoke
Yes	106	73	36	29
No	42	38	24	11
TNM stage
0	3		1
I (IA + IB)	17 (7 + 10)		8 (3 + 5)
II (IIA + IIB)	48 (22+ 26)		20 (4 + 16)
III (IIIA + IIIB + IIIC)	76 (32+ 14+ 30)		30 (15+ 2 + 13)
IV	4		1
Histological grade
High (grade 1)	50		17
Middle (grade 2)	84		36
Low (grade 3)	14		7
Depth of tumor invasion
Tis	3		1
T1	11		10
T2	19		11
T3	77		20
T4	38		18
Regional lymph nodes
N0	77		31
N1	38		19
N2	21		9
N3	12		1
Size of tumor
<5 cm	71		24
≥5 cm	77		36
Site of tumor
Upper thorax	15		10
Middle thorax	101		46
Lower thorax	32		4