Longitudinal Assessment of Transorbital Sonography, Visual Acuity, and Biomarkers for Inflammation and Axonal Injury in Optic Neuritis

Table 2

Sonographic features and visual outcomes of patients and OPN and NfH values assessed at baseline (T0) and after 1 year (T12) of follow-up.

Parameter	T	ON patients affected eye ()	Healthy controls ()	value
ONSD, mm	T0	6.3 (6.0–6.5)	5.2 (4.8–5.5)	<0.001
	T12	5.3 (4.9–5.6)
	value	<0.001
OND, mm	T0	3.4 (2.9–3.8)	2.7 (2.5–2.9)	<0.001
	T12	2.8 (2.7–3.0)
	value	0.001
Visual acuity	T0	0.80 (0.40–1.00)
	T12	1.00 (0.90–1.00)
	value	<0.001

T: time; ON: optic neuritis; ONSD: optic nerve sheath diameter, mm; OND: optic nerve diameter, mm; mm: millimeter; OPN: osteopontin; NfH: neurofilament heavy chain; ng/ml: nanogramm/milliliter; n: number of patients. Data are reported as median (IQR).