Longitudinal Assessment of Transorbital Sonography, Visual Acuity, and Biomarkers for Inflammation and Axonal Injury in Optic Neuritis

Table 3

OPN and NfH values assessed at baseline (T0) and after 1 year (T12) of follow-up.

Parameter	T	Patients	Healthy controls ()	value
OPN, ng/ml	T0	6.44 (2.05–10.06)	3.21 (1.34–4.34)	<0.03
	T12	6.70 (3.85–10.90)
		0.24
NfH, ng/ml	T0	0.39 (0.21–0.55)	0.02 (0.02–0.08)	<0.001
	T12	0.3 (0.21–0.48)
		0.94

OPN: osteopontin; NfH: neurofilament heavy chain; ng/ml: nanogramm/milliliter; n: number of patients. Data are reported as median (IQR). 23 patients underwent OPN measurements at T0 and T12, and 19 patients underwent NfH measurements at T0 and T12.