Serum HMGB1 as a Potential Biomarker for Patients with Asbestos-Related Diseases

Table 3

AUC and cut-off value of HMGB1 comparing healthy controls, AE, and ARDs.

	AUC (95% CI)	value	Cut-off (ng/ml)	Sensitivity (%)	Specificity (%)
MPM versus healthy	0.94 (0.89~0.99)	<0.0001	52.16	100	80.28
Asbestosis versus healthy	0.88 (0.82~0.95)	<0.0001	47.11	93.55	70.42
MPM versus AE < 10 Y	0.81 (0.73~0.90)	<0.0001	52.29	100	57.65
MPM versus AE ≥ 10 Y	0.80 (0.72~0.89)	0.0001	52.39	100	57.36
Asbestosis versus AE < 10 Y	0.74 (0.66~0.83)	<0.0001	58.43	61.29	77.06
Asbestosis versus AE ≥ 10 Y	0.74 (0.64~0.83)	<0.0001	56.48	64.52	72.09
PP versus healthy	0.68 (0.60~0.77)	0.0001	47.01	59.26	70.42
MPM versus asbestosis	0.56 (0.39~0.73)	0.5043	51.64	100	29.03

AUC: area under the curve; CI: confidence interval; AE: asbestos-exposed subjects; ARDs: asbestos-related diseases.