Does MMP-9 Gene Polymorphism Play a Role in Pituitary Adenoma Development?

Table 2

Frequency of MMP-9 (–1562 C/T) genotype in the patients with pituitary adenoma (PA) and in the control group.

Gene marker	Genotype/allele	Frequency (%)
		Control group; (%); ()	HWE	PA group; (%); ()	HWE	value
MMP-9 (–1562) Rs3918242	Genotype
	C/C		0.469		0.0029	p = 0.003
	C/T
	T/T	17 (3.2)		4 (4.7)
	Total	526 (100)		86 (100)
	Allele
	C	849 (80.70)		152 (88.37)
	T	203 (19.30)		20 (11.63)

MMP, matrix metalloproteinase; value, significance level (alpha = 0.05); value HWE, significance level (alpha = 0.05) by Hardy-Weinberg equilibrium.
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