Does MMP-9 Gene Polymorphism Play a Role in Pituitary Adenoma Development?

Table 6

Frequency of MMP-9 (–1562 C/T) genotypes in the patients with pituitary adenoma (PA) and in the control group by PA invasiveness.

Gene marker	Genotype/allele	Frequency (%)
		Control group; (%); ()	HWE	Noninvasive PA group; (%); ()	HWE	Invasive PA group; (%); ()	HWE
MMP-9 (–1562); Rs3918242	Genotype
	C/C	340 (64.6)^1,2	0.469	36 (81.8)^1	0.507	34 (81.0)^2	<0.001
	C/T	169 (32.1)^3		8 (18.2)		4 (9.5)^3
	T/T	17 (3.2)		0 (0)		4 (9.5)
	Total	526 (100)		44 (100)		42 (100)
	Allele
	C	849 (80.70)		80 (90.91)		72 (85.71)
	T	203 (19.30)		8 (9.09)		12 (14.29)

MMP, matrix metalloproteinase; value, significance level (alpha = 0.05); value HWE, significance level (alpha = 0.05) by Hardy-Weinberg equilibrium.
= 0.021.
= 0.041.
= 0.001.