Does MMP-9 Gene Polymorphism Play a Role in Pituitary Adenoma Development?

Table 8

Frequency of MMP-9 (–1562 C/T) genotype in the patients with pituitary adenoma (PA) and in the control group by PA activity.

Gene marker	Genotype/allele	Frequency (%)
		Control group; (%); ()	HWE	Inactive PA group; (%); ()	HWE	Active PA group; (%); ()	HWE
MMP-9 (–1562) Rs3918242	Genotype
	C/C	340 (64.6)^1	0.469	30 (100)^1,3	0.007	40 (71.4)^3	0.044
	C/T	169 (32.1)^2		0 (0)^2,4		12 (21.4)^4
	T/T	17 (3.2)		0 (0)		4 (7.1)
	Total	526 (100)		30 (100)		56 (100)
	Allele
	C	849 (80.70)		60 (100)		92 (82.14)
	T	203 (19.30)		0 (0)		20 (17.86)

MMP, matrix metalloproteinase; value, significance level (alpha = 0.05); value HWE, significance level (alpha = 0.05) by Hardy-Weinberg equilibrium.
< 0.001.
< 0.001.
< 0.001.
< 0.007.